| abstract |
The present invention features a method for treating sepsis. The method includes administrating to a subject in need thereof an effective amount of a fused pyrazolyl compound of formula (I): n n nA is H, C 1 ˜C 6 alkyl, or n n nin which n is 0, 1, 2, or 3; each of Ar 1 , Ar 2 , and Ar 3 , independently, is phenyl, pyridinyl, thienyl, furyl, or pyrrolyl; and each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , independently, is XYZ; or R 1 and R 2 together, R 3 and R 4 together, or R 5 and R 6 together are O(CH 2 ) 1-6 O; in which X is a bond or C 1 ˜C 6 alkylene, Y is a bond, O, S, OC(O), OC(O)(CH 2 ) 1-6 C(O)O, C(O)O, C(O)S, C(O)NH, C(O)NC 1 ˜C 6 alkyl, NH, or NC 1 ˜C 6 alkyl, and Z is H, halogen, CN, NO 2 , or C 1 ˜C 6 alkyl; and provided that one of R 3 and R 4 is not H. |