| abstract |
Substituted cycloalkyl compounds with 3 to 6 carbon atoms in the ring, one carbon linked to each of two side groups R and R′, and pharmaceutically acceptable salts thereof in which R is phenyl optionally substituted by one or more halo substituents or R is naphthyl; and R′ is —[X—Y—S(O) m -Z-N—R 1 —R 2 ], wherein X is carbonyl or a carbon directly linked to each of a hydroxyl group and R 5 in which R 5 is H or alkyl, Y is an alkylene chain optionally substituted by one or more alkyl groups, m can be 0, 1 or 2, Z is an alkylene chain containing 2 to 5 carbon atoms optionally substituted by one or more alkyl groups, and R 1 and R 2 , which are the same or different, are H, alkyl, or arylalkyl, provided that when R 1 is benzyl, R 2 is H or methyl; have utility in the treatment of drug misuse or other addictive disorders. |