http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005176999-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-363 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-43 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-363 |
| filingDate | 2003-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c3e58fa7cbc0d228bc6799521c6ae8b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e257e97753c74bec7dca170733467431 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4450218c4d1a470a0f2355b675d701a1 |
| publicationDate | 2005-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2005176999-A1 |
| titleOfInvention | Process for production of optically active 2-halogeno-carboxylic acids |
| abstract | The invention provides processes for producing efficiently optically active 2-halogenocarboxylic acids useful in the preparation of drugs or the like and salts thereof with amines. Specifically an optically active 2-halogenocarboxylic acid is produced by halogenating an optically active amino acid in water in the presence of a hydrophobic organic solvent and nitrous acid with the configuration retained and with the racemization inhibited through the removal of 2-hydroxy-bromocarboxylic acid formed as a by-product; the obtained optically active 2-halogenocarboxylic acid is transferred to an aqueous phase by converting it into a salt thereof with a base, followed by the removal of the organic phase; and the optically active 2-halogenocarboxylic acid is transferred again to an organic solvent phase, followed by the removal of the aqueous phase, whereby an optically active 2-halogenocarboxylic acid is obtained through the removal of a halogen component. Further, a high-quality salt of an optically active 2-halogenocarboxylic acid with an amine can be obtained by a crystallization method wherein the amine is added over the period of ½ hour or longer either continuously or in portions and/or wherein the crystallization solvent consists of a hydrophobic organic solvent and a hydrophilic organic solvent. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11453648-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107879927-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105712864-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10202337-B2 |
| priorityDate | 2002-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 231.