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filingDate 2004-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_154de2f10d0244a9ec17a3001827ed94
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publicationDate 2005-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2005169848-A1
titleOfInvention Adjuvant activities of mutants of LT-Ila and LT-IIb enterotoxin lacking binding to ganglioside
abstract The present invention describes the adjuvant activity of mutants of LT-IIa and LT-IIb enterotoxin which lack ganglioside binding activity. The adjuvant activity of the LT-IIb(T13I) mutant is comparable to that of the wild type LT-IIb. The adjuvant activity of LT-IIa(T34I) mutant is also described which exhibits a late onset adjuvant activity. These mutants are useful for enhancing immune response to antigens.
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