| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e76490bed88751680a5fef9bc73892 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-755 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-755 |
| filingDate |
2005-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91d6af3749ddeeb976a3cfb805fe8eb9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1feb0b10f7ad591a19f827cc254df249
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21a35cb86c0bed7496f042e463487fd0 |
| publicationDate |
2005-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2005165221-A1 |
| titleOfInvention |
Methods for producing factor VIII proteins |
| abstract |
Methods are provided for purification of Factor VIII polypeptides by affinity chromatography and ion exchange chromatography, in which the eluate from the affinity column is diluted with a solution comprising higher salt concentration, or lower non-polar agent concentration than that of the elution solution, prior to passing the diluted solution through the ion exchange column. The affinity matrix may comprise a monoclonal antibody or a peptide ligand. The methods result in improved purification without significant yield loss. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11783931-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10947269-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3875106-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11749394-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3043813-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9133433-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10896749-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11081211-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11670409-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9488625-B2 |
| priorityDate |
1998-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |