| abstract |
The present invention relates to fatty acid analogues of the general formula I: R 1 -[x i -CH 2 ] n —COOR 2 ; wherein R 1 is; a C 1 -C 24 alkene with one or more double bonds and/or with one or more triple bonds, and/or, a C 1 -C 24 alkyne, and/or, a C 1-C 4 24 alkyl, or a C 1 -C 24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 2 -C 5 acyloxy or C 1 -C 4 alkyl, and; wherein R2 represents hydrogen or C 1 -C 4 alkyl, and; wherein n is an integer from 1 to 12, and; wherein i is an old number and indicates the position relative to COOR 2 , and; wherein X i independent of each other are selected from the group comprising, O, S, SO, SO 2 , Se and CH 2 , and; with the proviso that at least one of the X i is not CH 2 ; which can be used for the treatment and/or prevention of inflammatory disorders. Further, the invention relates to methods for enhancing the endogenous production of interleukin-10 (IL-10) and suppressing the production of interleukin-2 in mammalian cells or tissues. The invention also relates to a method for inhibiting the proliferation of stimulated peripheral mononuclear cells. |