abstract |
Histone deacetylase inhibitors and uses thereof are provided that have the general n nZ-Q-L-M n wherein Z is a 5-membered aromatic heterocycle as shown herein, each X is independently selected from the group consisting of CR 5 and N; each Y is independently selected from the group consisting of O, S and NR 5 ; R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein; Q is a substituted or unsubstituted aromatic ring; M is a substituent capable of complexing with a protein metal ion; and L is a substituent comprising a chain of 1-10 atoms connecting the M substituent to the Q substituent. |