| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bdd619b8a2cc2f110b9ee4dc8d896a17 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate |
2004-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61f63810baa2cdccd86010ac435cc5ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16f24c86ab35a5e523774a0a8edf65d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e22000744a03932e4a4485fec58baec |
| publicationDate |
2005-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2005159432-A1 |
| titleOfInvention |
Short form c-Maf transcription factor antagonists for treatment of glaucoma |
| abstract |
The short form version of c-Maf transcription factor is up-regulated in steroid-treated and transforming growth factor beta2-treated trabecular meshwork cells, and is present at elevated levels in glaucomatous versus normal trabecular meshwork cells and in glaucomatous versus normal optic nerve head tissue. Expression of short form c-Maf transcription factor under these conditions indicates a causal or effector role for the factor in primary open-angle and steroid-induced glaucoma pathogenesis. Antagonism of short form c-Maf transcription factor expression and/or activity in the trabecular meshwork or other ocular tissue is provided for inhibiting or alleviating glaucoma pathogenesis. Antagonists include cyclin-dependent kinase 2 inhibitors. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8486620-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8618265-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011203023-P1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10718693-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7682789-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846320-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010184087-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010297725-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8703490-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005137146-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9719986-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005222127-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9017954-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005137147-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006115870-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008096238-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9575067-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8445191-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9103822-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008274463-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011144127-A1 |
| priorityDate |
2003-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |