| abstract |
Aza-quinolinol phosphonate compounds and methods for inhibition of HIV-integrase are disclosed. n n n Ar is aryl or heteroaryl connecting R 6 to L. L is a bond or a linker connecting a ring atom of Ar to N. The ring atoms, X 1 -X 5 may be N, substituted nitrogen, or substituted carbon, and form rings. The compounds include at least one phosphonate group covalently attached at any site. |