Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3425c4ec4507c9d893931783b923025b |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0312 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-706 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0339 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-033 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-00 |
filingDate |
2004-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0f762489c2f9ab308f94070fc53fcae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e1f628aa2fb458a45a49608b8dca4fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a21981615d7316bc98e0db514016551a |
publicationDate |
2005-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2005132422-A1 |
titleOfInvention |
Transgenic flies expressing Abeta42-Iowa |
abstract |
The present invention discloses a transgenic fly that expresses the Iowa mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42 Iowa peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008140449-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2977452-A2 |
priorityDate |
2003-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |