| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-026 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70557 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate |
2003-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a752344245a2b42bd8fd2b847520a19c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9babb403dded84c7afb8c8bd1cbbcef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e008b197d55206fd132ab5aef4b07749
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f89d9ed8f395d309cb1ebb238fd7f0c0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eff6dee1e84ad3343096bbebbfcc83ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12c1232d98ccfd27e49ef18994fbef67 |
| publicationDate |
2005-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2005130137-A1 |
| titleOfInvention |
Soluble recombinant alphavbeta3 adhesion receptor |
| abstract |
The invention relates to a novel purified recombinant α V β 3 adhesion receptor which shows an unimpaired ligand binding activity, and a process for preparing said soluble non-membrane bound receptor in excellent yields by recombinant techniques using a baculovirus-insect cell expression system. The so-synthesized soluble receptor may be used very easily as screening tool for new therapeutic compounds which may inhibit the natural α v β 3 adhesion receptor. Such therapeutic compounds which can be discovered very easily, fast and without health risk by means of the souluble receptors according to the invention may be, for example, RGD peptides or non-peptidic compounds mimicking the natural ligand epitopes. The invention relates, furthermore, to a corresponding process for preparing recombinant full-length α V β 3 adhesion receptor in excellent yields, additionally using detergents to dissolve the membrane bound receptor from the surface of the host cell. |
| priorityDate |
1996-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |