| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a933a0dd561e3e50b278738704d5c6e6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 |
| filingDate |
2002-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2935b3188eeaab34f8c3ca388d8e77ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f49a958e2a813d50d583e618dc61964c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_daf3f14fdde55d90c1bf7ccc3a4504ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7693dc81d5b80dc24c2b53e09092b84a |
| publicationDate |
2005-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2005123476-A1 |
| titleOfInvention |
Imaging the activity of extracellular protease in cells using mutant anthrax toxin protective antigens that are cleaved by specific extracellular proteases |
| abstract |
This invention pertains to methods for imaging the activity of extracellular proteases in cells using the anthrax binary toxin-system to target cells expressing extracellular proteases with mutant anthrax toxin protective antigens (μPrAg) that bind to receptors on the cells and are cleaved by a specific extracellular protease expressed by the cells, and ligands that specifically bind to the cleaved μPrAg and are linked to a moiety that is detectable by an imaging procedure. The μPrAg proteins used in the methods comprise a protease cleavage site that is cleaved by a specific extracellular protease and is in place of the furin cleavage site of the native PrAg. The methods are useful for diagnosing and treating diseases and undesirable physiological conditions correlated with the activity of extracellular proteases, and for optimizing the therapeutic efficacy of drugs used to treat such diseases and conditions. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013266568-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10323099-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10611825-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10640555-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7935345-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10793621-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9890204-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9879095-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10633457-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010178245-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11673945-B2 |
| priorityDate |
2001-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |