http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005119187-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4711 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0806 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1019 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-103 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 |
| filingDate | 2003-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c28cc92dd2c0e9e918db3249e963eeb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b49eccc50c7c13886a1e8340870e5266 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96e29b201380bb369cc1e25024de4c7b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59547af2e9dec7cfa1a146cb7cf47769 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cfdacc91a0997a5daba17bad8d251a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74d2d4907a59ce7c115f35fb451f46f9 |
| publicationDate | 2005-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2005119187-A1 |
| titleOfInvention | Anti-fibril peptides |
| abstract | Short peptides containing C α,α -dipropylglycine (Dpg) at alternating sequence positions were synthesized and examined for conformational behavior. Peptide assembly was performed using Fmoc-solid-phase chemistry where the coupling with PyAOP could be significantly enhanced at elevated temperature. Circular dichroism (CD) and NMR conformational studies revealed that incorporation of Dpg residues induced folded structures into peptides. It was observed that Dpg residues adopted helical conformation in a helix-promoting sequence. The resulting helical structure was comprised of consecutive β-turns whose structure was stabilized by salt bridge in aqueous solution. n In this study, the preparation of sterically and polyfunctional C α,α -disubstituted amino acids (ααAAs) via alkylation of ethyl nitroacetate and transformation into derivatives ready for incorporation into peptides are described. Treatment of ethyl nitroacetate with N,N-diisopropylethylamine in the presence of a catalytic amount of tetraalkylammonium salt, followed by the addition of an activated alkyl halide or Michael acceptor, gave the doubly C-alkylated product in good to excellent yields. Selective nitro reduction with Zn in acetic or hydrogen over Raney Ni gave the corresponding amino ester that, upon saponification, can be protected with the fluorenylmethyloxycarbonyl (Fmoc) group. The synthesis of a sterically demanding C α,α -dibenzylglycine (Dbzg), and an orthogonally protected, tetrafunctional C α,α -disubstituted analogue of aspartic acid Bcmg is described. n The preparation of amyloid fibril blocker peptides based on amyloid peptide hydrophobic core Aβ 16-20 is described. These blocker peptides containing sterically |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10987400-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013189606-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9717772-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010256069-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108530617-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106800590-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106800590-A |
| priorityDate | 2002-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 154.