| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-624
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6829
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6875
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate |
2002-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4086331fc5497c7773a76e9f85aac8f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1de4797f17cc9f55437c61fce63a22b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_546e9ccf59572045315cad7760e24500
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8712fbd5a57b2a45373abf5f11a7224 |
| publicationDate |
2005-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2005118182-A1 |
| titleOfInvention |
Mutated anti-cd22 antibodies with increased affinity to cd22-expressing leukemia cells |
| abstract |
Recombinant immunotoxins are fusion proteins composed of the Fv domains of antibodies fused to bacterial or plant toxins. RFB4 (Fv)-PE38 is an immunotoxin that targets CD22 expressed on B cells and B cell malignancies. The present invention provides antibodies and antibody fragments that have improved ability to bind the CD22 antigen of B cells and B cell malignancies compared to RFB4. Immunotoxins made with the antibodies and antibody fragments of the invention have improved cytotoxicity to CD22-expressing cancer cells. Compositions that incorporate these antibodies into chimeric immunotoxin molecules that can be used in medicaments and methods for inhibiting the growth and proliferation of leukemia and lymphoma cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9701748-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101552735-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10494435-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008070569-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1999148-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022068899-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007258981-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8734792-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1998799-A2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015130416-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2650306-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011020344-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008118505-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7829086-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009142341-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10072083-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9279019-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010143368-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10183998-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9944703-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9499632-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9238878-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9540438-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007264260-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2639242-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8664363-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8389688-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011182887-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9879249-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1999148-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1998799-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9518115-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8907060-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11136396-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8481683-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9580461-B2 |
| priorityDate |
2001-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |