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filingDate 2004-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a21981615d7316bc98e0db514016551a
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publicationDate 2005-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2005108779-A1
titleOfInvention Transgenic flies expressing Abeta42-Italian
abstract The present invention discloses a transgenic fly that expresses the Italian mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42 Italian peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10478511-B2
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priorityDate 2003-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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