http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005106637-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4712 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6887 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2004-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49e9dbdfba635b99835076250bb55333 |
| publicationDate | 2005-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2005106637-A1 |
| titleOfInvention | Methods for assessing muscle protein wasting and therapeutics therefor |
| abstract | The present disclosure provides evidence that actin degradation, in particular to produce a proteolytic fragment of about 14 kDa, is an important marker of muscle protein wasting. Muscle biopsy samples from a patient suffering from, susceptible to, or treated for a catabolic condition are tested for the production of an actin cross reacting protein of about 14 kDa, as estimated by SDS-PAGE. The presence of this actin fragment is diagnostic of muscle protein wasting (catabolism) in a muscle biopsy sample. Where a treatment for the catabolic disorder and/or muscle protein wasting is given, the failure to observe reductions in the amount of the actin degradative product is diagnostic of a treatment which is not effective to ameliorate or prevent the wasting. Animal models in which there is muscle protein wasting, e.g., streptozotocin-treated diabetic rates, can be used to identify inhibitors of wasting by reduction in actin fragments in muscle biopsy specimens of treated animals. Inhibitors identified in an animal model (or a cell culture model) can be used to prevent or decrease muscle wasting in a patient with a catabolic illness or used to increase muscle mass in a normal human or animal, an animal or human recovering from a catabolic illness or in a farm animal. |
| priorityDate | 2000-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 178.