| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-523
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-23 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-095 |
| filingDate |
2003-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d6977f42a2cf6edea89e5b7dcfcf69e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7863858a6452f8dd6de2d2c3b95040f0 |
| publicationDate |
2005-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2005106184-A1 |
| titleOfInvention |
Neisseria mutants, lipooligosaccharides and immunogenic compositions |
| abstract |
Provided herein are mutant strains of Neisseria meningitidis which produce Kdo-free lipid A as well as the Kdo-free lipid A molecules and immunogenic compositions containing such Kdo-free lipid A molecules from a Neisseria strain containing a genetically stable mutation which inactivates a gene selected from the group consisting of genes encoding arabinose-5-phosphate isomerase, CMP-Kdo synthetase and CMP-Kdo transferase. N. meningitidis NMB206 is a specifically exemplified strain which harbors a stable insertion mutation in the gene (ApsF) encoding A5P isomerase; strain NMB-249 is a specifically exemplified strain with a stable insertion mutation in the gene (kdtA) encoding CMP-Kdo synthetase, and strain NMB259 is specifically exemplified strain with a stable insertion mutation in the gene (kdsB) encoding CMP-Kdo transferase. Also provided by the present invention are methods for the production of Lipid A flee of 3-keto-3-deoxyoctanoic acid using these genetically stable N. meningitidis mutants. Also describes is pYT250, a plasmid functional in neisseriae and in enterics such as Escherichia coli. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011165067-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008058116-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010272758-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006073168-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10711043-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009523810-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011224097-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8303964-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7883876-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9068186-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007084633-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010055127-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10017545-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9603977-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9603979-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009208533-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012308632-A1 |
| priorityDate |
2002-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |