| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2001-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbae8e03964be76389438ceff3963bea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_639a85403522dd8b5039bfea468f2901
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27590c1af405ea250cc01b46f11e2f18 |
| publicationDate |
2005-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2005101766-A1 |
| titleOfInvention |
Method of identifying modulators of presenilin |
| abstract |
A method of identifying a modulator of presenilin function, the method comprising: (i) providing (a) a polypeptide capable of binding a presenilin, which polypeptide comprises the amino acid sequence of SEQ ID NO: 1 or a functional variant thereof, or a fragment of either thereof which is capable of binding to presenilin; (b) a presenilin or a variant thereof or a fragment of either thereof capable of binding to a polypeptide which comprises the amino acid sequence of SEQ ID NO: 1; (c) a test substance under conditions that would permit binding of a polypeptide (a) to a presenilin (b) in the absence of the test substance; (ii) monitoring presenilin mediated activity; and (iii) determining thereby whether the test substance is a modulator of presenilin activity, a modulator identified by a method of the invention and use of a modulator identified by a method of the invention in the treatment of Alzheimer's disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7851228-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8945858-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8389478-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007231331-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8129334-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009305946-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9512191-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10774121-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8951794-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10221223-B2 |
| priorityDate |
2000-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |