| abstract |
A novel compound represented by the formula (1): n n n[R 1 represents hydrogen atom, chlorine atom, or hydroxyl group; X 1 . . . X 2 represents —CH(R 2 )—CH(R 3 )—, —CH(R 2 )—CH(R 3 )—CH(R 4 )—, etc.; R 2 to R 4 represent hydrogen atom, or an alkyl group; A 1 , A 11 , A 2 , and A 21 represent hydrogen atom, or an alkyl group; Y represents —CH(A 3 )-, —CH(A 3 )-C(A 4 )(A 41 )-, —CH(A 3 )-C(A 4 )(A 41 )-C(A 5 )(A 51 )-, or a single bond; A 3 , A 4 , A 41 , A 5 , and A 51 represent hydrogen atom, or an alkyl group; Z represents hydroxyl group, or —N(A 6 )(A 61 ); A 6 represents hydrogen atom, or an alkyl group, A 61 represents hydrogen atom, an alkyl group, an aralkyl group, etc.; and groups in each of one or more combinations selected from the group consisting of combinations of A 6 and A 3 , A 6 and A 4 , A 6 and A 1 , A 6 and A 2 , A 2 and A 3 , A 2 and A 4 , A 6 and A 5 , A 3 and A 1 , and A 5 and A 1 may bind to each other to form a 5- or 6-membered ring], or a salt thereof, which potently inhibits the phosphorylation of myosin regulatory light chain. |