http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005090445-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0fc19d8d6ba9ad5c1fa5770341472b56 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-642 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-50 |
| filingDate | 2004-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89b3dac7523b31e61dd7cf63602c44ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_750670562718cb16c361a0883c793acb |
| publicationDate | 2005-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2005090445-A1 |
| titleOfInvention | Truncated keratinocyte growth factor (KGF) having increased biological activity |
| abstract | The present invention relates to a keratinocyte growth factor fragment, KGF des1-23 , or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF 163 . The fragment exhibits at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- (SEQ ID NO: 2) of the KGF 163 N-terminus. The present invention also relates to a DNA molecule encoding KGF des1-23 , an expression vector and a transformed host containing the DNA molecule, and a method of producing KGF des1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGF des1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidernis. Moreover, the present invention relates to a therapeutic composition containing KGF des1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes. |
| priorityDate | 1993-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 404.