| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8268e39ce70ff2ad19742e2a21d5a90c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-142
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6809
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6809
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 |
| filingDate |
2004-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b137e033c24eae1d4218c1bca3fc4e03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69c20541d95a3c5c784c34177cfba285
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd332fd6e2539cd89cf87992ee7ea488
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f56f527191e3862b7b80cdc90855af2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8975c06bd44ac53ca987b1d4a916cc0 |
| publicationDate |
2005-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2005084896-A1 |
| titleOfInvention |
Process to study changes in gene expression in granulocytic cells |
| abstract |
The present invention comprises a method to identify granulocytic cell genes that are differentially expressed upon exposure to a pathogen or in a sterile inflammatory disease by preparing a gene expression profile of a granulocytic cell population exposed to a pathogen or isolated from a subject having a sterile inflammatory disease and comparing that profile to a profile prepared from quiescent granulocytic cells. The present invention is particularly useful for identifying cytokine genes, genes encoding cell surface receptors and genes encoding intermediary signaling molecules. The invention also includes methods to identify a therapeutic agent that modulates the expression of at least one gene in a granulocyte population. Genes which are differentially expressed during neutrophil contact with a pathogen, such as a virulent bacteria, or that are differentially expressed in a subject having a sterile inflammatory disease are of particular importance. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11111514-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010129874-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8936912-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9909170-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012289414-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8586310-B2 |
| priorityDate |
1997-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |