abstract |
The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally n nb) isolating the obtained sulphoxide of formula (I); n n n wherein n, Y, R 1 , R 1a , R 2 and R 2a are as defined herein. |