| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5748
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-30 |
| filingDate |
2004-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7ce39bdc328fe7c72c24ee449035c3e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dddf22d328f8b0602ef93dac1a6d8d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16ac1313c36ed9839a2e35fe5e3b9b6b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6cc89e3434d689bc6c0d197e5a285c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c832a29d737f977f91112c4723e9cfe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7acc7b2f4a5823f5f35819078430713b |
| publicationDate |
2005-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2005080102-A1 |
| titleOfInvention |
Compound and uses thereof |
| abstract |
The subject invention relates to a novel small molecule, referred to as alpha-(trichloromethyl)-4-Pyridineethanol (PETCM), as well as to uses thereof. PETCM was identified and isolated by high throughput screening and is an activator of caspase-3. Using PETCM in combination with biochemical fractionation, a novel pathway that regulates mitochondria-initiated caspase activation was also identified. This pathway comprises tumor suppressor PHAP proteins and oncoprotein prothymosin-alpha. PETCM relieves prothymosin-alpha inhibition and allows apoptosome to form at a physiological concentration of dATP. |
| priorityDate |
2002-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |