http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005080053-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_945ae1209056dcb497edf108d69159da |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65616 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 |
| filingDate | 2004-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f77d576915ca57770c1a30bd5c0ac3ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31efb2f50f5506ed7e1f00fa3499b781 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc81cd2fc3c193d5f83d6e19efaa0dfb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_593d2d5dbfee6c82948959d65d43fd64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6f1dd952a004e792fe1410f6ac6674e |
| publicationDate | 2005-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2005080053-A1 |
| titleOfInvention | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| abstract | Compounds represented by the formula: n n n Wherein A is —(CH 2 ) n —R, —CH═CH 2 , —CH 2 —CH═CH 2 , —O—(CH 2 ) n —R, —CH(OH)CH 3 , —CH(OH)—CH 2 OH, —CH 2 —CH(OH)CH 3 , —CH 2 —CH(OH)—CH 2 OH, —CH(OH)—CH(OH)—CH 3 ; n R is H, OH, F, N 3 , NH 2 , CO 2 H, SH, alkyl, S-alkyl, O-acyl, CONH 2 , CONH-alkyl; n Z and Z′ independently is OR′, OR 2 , O—(CH 2 ) n —O-alkyl or aminoacids and esters thereof; n R 1 and R 2 independently is H, alkyl, aryl, pivaloyloxymethyl, phthalyl or substituted phthalyl, C(R 3 ) 2 OC(O) X (R 4 )a, n n n R 3 is —H, C 1 -C 12 alkyl, C 5 -C 12 aryl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 7 -C 12 alkenylaryl, C 7 -C 12 alkynylaryl, or C 6 -C 12 alkaryl, any of which is unsubstituted or is substituted with 1 or 2 halo, cyano, azido, nitro, or —OR 5 ; n R 4 is —H, C 1 -C 12 alkyl, C 5 -C 12 aryl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, C 7 -C 12 alkenylaryl, C 7 -C 12 alkynylaryl, or C 6 -C 12 alkaryl, any of which is unsubstituted or is substituted with 1 or 2 halo, cyano, azido, nitro, —N(R 6 ) 2 or —OR 5 ; n R 5 is C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl or C 5 -C 12 aryl; n provided that at least one R 4 is not H; and a is 1 when X is CH 2 , or direct bond, or 1 or 2 when X is N with the proviso that when a is 2 and X is N, (a) two N-linked R groups can be taken together to form a carbocyclic or oxygen containing heterocycle, (b) one N-linked R 4 additionally can be —OR 5 or (c) both N-linked R 4 groups can be —H; n R 6 is H or C 1 -C 8 alkyl; n R 7 is selected from H, alkyl, alkenyl, alkynyl, aryl, acyloxyalkyl, and pivaloyloxyalkyl; n is 1-3; Y is O, S or NH; W is O or S; B is selected from the group consisting of adenine, guanine, and modified purines are provided. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9580428-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006089066-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004014722-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019509288-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006122391-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7388002-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016531119-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008279819-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005033051-A1 |
| priorityDate | 2003-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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