http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005058646-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 2004-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab1e93fe3b0449d710765f6ed9a513d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d422022d9ef980501b861ad279e33aed |
| publicationDate | 2005-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2005058646-A1 |
| titleOfInvention | Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyalurons |
| abstract | The present invention provides compositions and methods for treating a tissue disorder associated with a response-to-injury process or proliferating cells in a mammal. These tissue disorders are associated with a novel cellular phenotype designated as “transition cells” which are described herein. This cellular phenotype is characterized in having an activated erk kinase signaling activity, a stimulated AP-1 binding activity, and at least one characteristic selected from the group consisting of: (a) increased podosome formation, (b) increased flux of intracellular or extracellular hyaluronans or hyaladherins, (c) increased expression of a hyaladherin, (d) an inability to form focal adhesions, (e) increased metalloproteinase activity, and (f) increased expression of a hyaladherin. Example tissue disorders include fibrosis, inflammation, degeneration and invasive disorders such as occur in cancerous cells. The methods provided herein include administering to the mammal, an effective amount of a composition that alters the activity of transition molecules within a cell Transition molecules are shown to be comprised of hyaladherins, hyaluronans and associated molecules that regulate the transitional phenotype. A novel cell culture comprising transition cells is also provided, as well as compositions comprising particular peptides, polypeptides, and antibodies that affect the transitional phenotype. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10844102-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9890197-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10562935-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8715653-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10494402-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008140499-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008140586-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015184125-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010143382-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9090659-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2007353332-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008140499-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10766927-B2 |
| priorityDate | 1999-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1527.