Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_332b293f8a27d8dfcc89af550267b295 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2121-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6825 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2896 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
filingDate |
2003-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6fd0b4dcd69b60e0311e939dddd7794 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a585715e257a664d2443a5f86d42a4bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25b94a0188d198eb8cffa56c139d81de |
publicationDate |
2005-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2005054835-A1 |
titleOfInvention |
Immunotoxins comprising ribosome-inactivating proteins |
abstract |
The present invention provides purified and isolated polynucleotides encoding Type I ribosome-inactivating proteins (RIPs) and analogs of the RIPs having a cysteine available for disulfide bonding to targeting molecules. Vectors comprising the polynucleotides and host cells transformed with the vectors are also provided. The RIPs and RIP analogs are particularly suited for use as components of cytotoxic therapeutic agents of the invention which include gene fusion products and immunoconjugates. Cytotoxic therapeutic agents or immunotoxins according to the present invention may be used to selectively eliminate any cell type to which the RIP component is targeted by the specific binding capacity of the second component of the agent, and are suited for treatment of diseases where the elimination of a particular cell type is a goal, such as autoimmune disease, cancer and graft-versus-host disease. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11312751-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11225509-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10450354-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11248061-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11142584-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11104707-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11365223-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014003536-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014003537-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11406692-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10815469-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11389542-B1 |
priorityDate |
1991-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |