abstract |
Compounds according formula (I) A-G-Z-W and pharmaceutically acceptable salts, solvates or hydrates thereof; wherein, n A is (C 6 -C 10 )aryl, (C 6 -C 10 )aryl-SO 2 , (C 6 -C 10 )aryl-CH 2 —, (C 6 -C 10 )arylcarbonyl, (C 1 -C 9 )heteroaryl, (C 1 -C 9 )heteroaryl-SO 2 —, (C 1 -C 9 )heteroaryl-CH 2 —; or (C 1 -C 9 )heteroarylcarbonyl; n nG is selected from the group consisting of: n n nwhere B is (C 6 -C 10 )aryl or (C 1 -C 9 )heteroaryl, and X is CH 2 , SO 2 , or carbonyl; n n nwhere X is CH 2 , SO 2 , or carbonyl; and R 1 and R 1′ are each independently selected from H, CN, (C 1 -C 8 )alkyl-, and phenyl(CH 2 )—, wherein said alkyl and phenyl groups are optionally substituted; and n nwhere Z and W are as defined in the present Specificiation; and pharmaceutical compositions and methods useful to increase secretion of growth hormone(GH) from the anterior pituitary of mammals, including on a sustained release basis. |