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filingDate 2002-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_caa0fc891995a1b0add9ba36247dcc4b
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publicationDate 2005-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2005054105-A1
titleOfInvention Adenoviral vector system
abstract The invention relates to an adenoviral vector on the base of human group B adenoviruses, specially of the subtype 11 containing as per invention heterologous elements, inverted terminal repeats (ITRs) in combination with the respective packaging signal of a different serotype virus, preferably of a type B virus. A heterologous promoter, preferably the SV40 promoter is contained and positioned between the packaging signal and the natural position for protein IX in the viral vector. This vector may be additionally deleted in reading frames of the regions E1, E2, E3 or E4. The invention also describes the use of this viral vector for the production of a high capacity vectors based on adenovirus 11, in which the only adenoviral sequences are ITRs and packaging signal and which contains human genomic stuffer sequences. Moreover, cell lines for the amplification of these viral vectors and application of the vectors in medicine are described.
priorityDate 2001-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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