| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae84948901b77f34fd51c41264d8d19c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06139 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate |
2004-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eae5413f22cbf86b498280eed6c36e71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a12d001aba464382e5957f5d99cd46ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a137244758211732836ed1880914640a |
| publicationDate |
2005-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2005038012-A1 |
| titleOfInvention |
Solid salts of benzazepine compounds and pharmaceutical compositions containing them |
| abstract |
Pharmaceutically acceptable metal salts of compounds of formula (I): n nin which n R 1 is selected from the group consisting of (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl which may be substituted with (C 1 -C 6 )alkoxy, phenyl-(C 1 -C 6 )-alkyl and/or phenyloxy-(C 1 -C 6 )-alkyl group in which any phenyl group may be substituted with (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy or halogen, and naphtyl-(C 1 -C 6 )-alkyl; R 2 and R 3 are each independently hydrogen or halogen; R 4 is a biolabile ester forming group; and in which the salt is selected from the lithium salt and salts of bivalent metal ions such as magnesium, calcium and zinc. Also described are a method for the preparation of the above salts; pharmaceutical compositions comprising the above salts; methods of using the above salts to treat heart disorders or hypertension, to improve gastrointestinal blood flow, or to treat or inhibit cardiac damage induced by adriamycin and comparable anti-cancer drugs; and crystalline S-α-methylbenzylamine salts of the compounds of formula (I) that are useful as intermediates in production of the above salts. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009306117-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006205625-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7816347-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006189595-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005267124-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010323012-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9174945-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006159748-A1 |
| priorityDate |
2002-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |