| abstract |
The present invention relates, in part, to the discovery that injectable extended release formulations possess an unexpected advantage in treating patients classified as CYP 2D6 UM and/or EM. This advantage is particularly beneficial where the metabolite is increasingly water soluble, as compared to the parent drug, and/or possesses a decreased mobility across the blood brain barrier. Thus, the invention relates to a method for treating individuals possessing a functional CYP 2D6 gene with an active agent metabolized by CYP 2D6 comprising injecting the active agent in a first extended release formulation in a first administration, and the formulations for use in such methods. The invention further includes a method for preventing adverse drug reactions in individuals possessing a functional CYP 2D6 gene with an active agent metabolized by CYP 2D6 comprising injecting the active agent in a first extended release formulation in a first administration. |