| abstract |
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable salts thereof; wherein R 1 is a C 2 -C 20 substituted or unsubstituted carboxyacyl or ester thereof; R 2 is hydrogen, halogen, hydroxyl or —OR 3 , R 3 is C 2 -C 20 substituted or unsubstituted carboxyacyl; and R 4 is hydrogen or C(C 6 H 5 ) 3 ; wherein the dashed line represents an optional double bond between C20 and C29. |