| abstract |
A method for the simultaneous, parallel, selective enrichment of different DNA segments which are obtained from different tissues by complex amplifications and have desired individual sequence properties is described. These properties of the DNA fragments, particularly the presence of 5-methylcytosines, can be identified by hybridization on DNA microarrays. The desired DNA fragments are enriched by several repetitions of the operating steps (hybridization, dehybridization and reamplification). The method combines the SELEX method with complex DNA arrays, which are used for the enrichment of DNA fragments. The sequence of the amplificates is then analyzed. |