| abstract |
The present invention is a compound and pharmaceutical composition comprising a compound of formula (I): n n n where R 1 is an N-containing heterocyclic group selected from an imidazolyl, a triazolyl, a pyridyl, a pyridazinyl, a pyrimidinyl and a pyrazinyl group, each of which may be substituted with one or more lower alkyl groups, R 2 is a hydrogen atom or a lower alkyl group, and R 3 is a phenyl group substituted with thienyl or halophenyl; a thienyl group substituted with thienyl, phenyl or halophenyl; a pyrrolyl group substituted with phenyl; a thiazolyl group substituted with phenyl; an indolyl group substituted with lower alkyl and/or halo(lower)alkyl; a fluorenyl group; or a carbazolyl group which is unsubstituted or substituted with a fluorine atom. The compound of formula (I) includes pharmaceutically acceptable salts. The compound of formula (I) and salts thereof have 5 -HT antagonism activity. |