| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eeeae0737010cc824f88389d81c24035 |
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| classificationCPCInventive |
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01108
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01062 |
| classificationIPCAdditional |
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| classificationIPCInventive |
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18
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| filingDate |
2004-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7901a04c734a19a728eaac44605a5473
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b023c1a5d3dc7e328314aad09599147
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20fa7512c1d284ca0eb5d8273d40a4d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaefd76c1896016ec26843b29fdd0026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d2f566f26aa848fc7d54f2aa90f0dfa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ad8a0ff28932cc4b0c03b0c8b82ac23 |
| publicationDate |
2004-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004265856-A1 |
| titleOfInvention |
Identification of a DNA variant associated with adult type hypolactasia |
| abstract |
The present invention relates to a nucleic acid molecule comprising a 5′ portion of an intestinal lactase-phlorizine hydrolase (LPH) gene contributing to or indicative of the adult-type hypolactasia wherein said nucleic acid molecule is selected from the group consisting of (a) a nucleic acid molecule having or comprising the nucleic acid sequence of SEQ ID NO: 1, the sequence of SEQ ID NO:1 is also depicted in FIG. 4 and comprised in the sequence as depicted in FIG. 8 ; (b) a nucleic acid molecule having or comprising the nucleic acid sequence of SEQ ID NO: 2, the sequence of SEQ ID NO:2 is also depicted in FIG. 5 and comprised in the sequence as depicted in FIG. 9 ; (c) a nucleic acid molecule of at least 20 nucleotides the complementary strand of which hybridizes under stringent conditions to the nucleic acid molecule of (a) or (b), wherein said polynucleotide/nucleic acid molecule has at a position corresponding to position −13910 5′ from the LPH gene a cytosine residue; and (d) a nucleic acid molecule of at least 20 nucleotides the complementary strand of which hybridizes under stringent conditions to the nucleic acid molecule of (a) or (b), wherein said polynucleotide/nucleic acid molecule has at a position corresponding to position −22018 5′ from the LPH gene a guanine residue. The present invention further relates to methods for testing for the presence of or predisposition to adult-type hypolactasia that are based on the analysis of an SNP contained in the above recited nucleic acid molecule. Additionally, the present invention relates to diagnostic composition and kit useful in the detection of the presence of or predisposition to adult-type hypolactasia. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004142326-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009148915-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008220429-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8030036-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011104689-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009098087-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8236297-B2 |
| priorityDate |
2001-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |