| abstract |
The invention relates to an orodispersible effervescent tablet comprising at least one active ingredient, a mixture of excipients comprising at least one disintegrating agent, a diluting soluble agent, a luficating agent and, optionally, an internal dehydrating agent, a swelling agent, a permeabilizing agent, sweetening agents, flavouring agents and colorants, and effervescent granules based on a mixture which is essentially composed of an acidic agent, a heat extrudable binding agent and an alkaline agent and, optionally, a dehydrating agent and a lubricant, said granules being prepared by means of heat extrusion in the absence of of water and solvents, and said tablet disintegrating in the pharynx when it comes into contact with saliva in at least 60 seconds and preferentially in less than 40 seconds. |