| abstract |
The invention relates to derivatives corresponding to formula I: n n n in which n X is an alkyl-(CH 2 ) n — chain with n=0, 1 or 2, or O or N, n Z is an aromatic which may contain heteroatoms chosen from O, N or S, as substitutions for the carbon atoms constituting said aromatic ring, this ring being substituted or otherwise with Rb, n Rb represents 1 to 3 substituents chosen from —OH, —OR, —COOH, —COOR, —COH, —COR, —NH 2 , —NH(R), —NH(R,R′), —SH, —SR and CN, n Ra is H or —(CH 2 ) n′ —Y, with n′=0, 1, 2 or 3 and Y and —CH 3 , —COOH, —COOR, —CN, —OH, —OR, SR, or an aryl group optionally substituted with Rb, n R and R′ represent a linear or branched alkyl chain of 1 to 4C, and their pharmaceutically acceptable salts. Application as active ingredient of medicaments inhibiting retrovirus integrases. |