| abstract |
The present invention relates generally to the control of metabolic disorders, such as body weight disorders, of animals including mammals and humans, and more particularly to polypeptides identified herein as modulators of metabolic disorders, and to diagnostic and therapeutic uses of such modulators. In its broadest aspect, the present invention relates to mammalian neuronatin proteins sequences, isoforms thereof, and degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian metabolism and that have been postulated to play a critical role in the regulation of body weight, adiposity and non-insulin dependent diabetes mellitus (NIDDM). The invention further relates to the preparation of the modulators of the invention. |