| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9121 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-99
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 |
| filingDate |
2004-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd1790f1030a29c75b4afa29d1d162da
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5514214f5ba4fcf609e6e6862e44261
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ab2779a1b87439dca650839ec6280c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f95d8ef015a4bc11552a06d8aeef08ec |
| publicationDate |
2004-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004259166-A1 |
| titleOfInvention |
Methods for designing inhibitors of serine/threonine kinases and tyrosine kinases |
| abstract |
The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8097408-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009170720-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8673268-B2 |
| priorityDate |
1998-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |