| abstract |
The present invention relates compounds of the formula (I); wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 10 represent a variety of substituents; A represents NR 9 or O; B represents a bond, CH 2 , NR 9 or O, wherein one or both hydrogen atoms in said CH 2 moiety may be replaced with one or both of R 7 and R 8 , or alternatively, one of the hydrogen atoms in said CH 2 moiety together with a hydrogen atom from an adjacent carbon are replaced by a double bond; with the proviso that when A is O, then B is NR 9 ; n is zero, 1 or 2; and pharmaceutically acceptable salts thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia. |