http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004248877-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D245-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D339-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D245-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D339-00 |
| filingDate | 2004-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9c4360f785a95979abd1116c9f88511 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1840f46140e982892d0680256b2fd1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec3acc97e4145f81856c69393bcd5e53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98fd49785e002f0c71d90395b97ca992 |
| publicationDate | 2004-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004248877-A1 |
| titleOfInvention | Polycyclic diazodioxide-based Bcl-2 protein antagonists and use thereof |
| abstract | Compounds of Formula 8 are provided: n n n A and B are each independently selected from the group consisting of —NO—, —SO—, and —NR 9 —. C is a single bond or a double bond. D is selected from the group consisting of single bond, n n n E is selected from the group consisting of single bond, double bond, —NR 9 —, —O—, —S—, —SO—, and —SO 2 —; and m and n are each independently an integer from 0 to 6. R 1 to R 9 are appropriately selected to optimize physicochemical and/or biological properties such as lipophilicity, bioavailability, pharmacokinetics, Bcl-2 and Bcl-X L activities, metabolism, and the like. R 1 and R 2 , R 2 and R 3 , R 3 and R 4 , R 5 and R 6 , R 6 and R 7 , or R 7 and R 8 may optionally be joined together to form an aromatic or heteroaromatic ring, including, but not limited to, naphthyl, quinolinyl, isoquinolinyl, benzimidazolyl, benzoxazolyl, benzothiazolyl and the like. The compounds are useful for tumor therapeutic applications. These compounds induce apoptosis in tumor cells mediated through Bcl-2 family of proteins. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10195213-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10426788-B2 |
| priorityDate | 2003-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 557.