| abstract |
The present invention relates to a 5-amidino-N-(2-aminophenethyl)-2-hydroxybenzenesulfonamide derivative represented by the general formula: n n n wherein R 1 is a hydrogen atom or a lower alkyl group; n R 2 represents a hydrogen atom, an optionally substituted lower alkyl group, etc.; n R 3 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, etc.; n Q is a hydrogen atom or an optionally substituted lower alkyl group; and n Z is a hydrogen atom or a hydroxy group, etc., n or a pharmaceutically acceptable salt thereof, which exerts a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof. |