http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004236086-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-252 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-252 |
| filingDate | 2004-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3ee4e3855f362513ccafc5d405910cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbf62fbfacece89002d8b2d1dee80d91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94edd33c3a60c7efe64fabe61a287559 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_544b1361bc9962060faf1deb628b9dac |
| publicationDate | 2004-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004236086-A1 |
| titleOfInvention | Method of preparing 4-R-substituted 4-demethoxydaunorubicin |
| abstract | A method of synthesizing 4-R-substituted anthracyclines and their corresponding salts from 4-demethyldaunorubicin includes the steps of treating 4-demethyldaunorubicin with a sulfonylating agent to form 4-demethyl-4-sulfonyl-R 3 -daunorubicin. 4-Demethyl-4-R 3 -sulfonyl-daunorubicin is then subject to a reducing agent in the presence of a transition metal catalyst in a temperature range of about 30° C. to about 100° C. in a polar aprotic solvent in an inert atmosphere. Protected 4-demethoxy-4-R-daunomycin then undergoes hydrolysis in a basic solution to form the 4-R-substituted anthracyclines. The novel method lacks the step of forming a stereospecific glycoside bond between aglycone and aminoglycoside. The method also increases the yield of the final product up to 30 to 40%. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012232971-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846882-B2 |
| priorityDate | 2003-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 185.