http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004234965-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4703 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2003-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9dec70dc44f1ec955948fd86f67421e |
| publicationDate | 2004-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004234965-A1 |
| titleOfInvention | Novel pathways involved in epigenetic memory |
| abstract | The molecular mechanisms by which central nervous system-specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and regulatory biology. The presently described invention outlines a dual mechanism of transcriptional downregulation in which the transcription factor REST/NRSF is a central component. The invention delineates short-term REST/NRSF-dependent active repression of neural-specific genes through the recruitment of histone deacetylases as well as long-term gene silencing through the recruitment of a novel biochemical complex which requires CpG methylation. Long-term silencing of neuronal-specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST/NRSF response elements. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011086043-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10166251-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9486469-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009045965-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009045965-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110190982-A |
| priorityDate | 2003-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 924.