http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004219607-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9723 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N23-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6803 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N23-20 |
| filingDate | 2004-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd2e80ed9e6c6b46d2a649f54547ea14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d507ba83883f9768a31c3927aa06da29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba27e547404010111d39206889cf6271 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5664a057f5a19befb83fd29fc3e8821 |
| publicationDate | 2004-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004219607-A1 |
| titleOfInvention | Ligand screening and design by X-ray crystallography |
| abstract | X-ray crystallography can be used to screen compounds that are not known ligands of a target biomolecule for their ability to bind the target biomolecule. The method includes obtaining a crystal of a target biomolecule; exposing the target biomolecule crystal to one or more test samples; and obtaining an X-ray crystal diffraction pattern to determine whether a ligand/receptor complex is formed. n The target is exposed to the test samples by either co-crystallizing a biomolecule in the presence of one or more test samples or soaking the biomolecule crystal in a solution of one or more test samples. In another embodiment, structural information from ligand/receptor complexes are used to design ligands that bind tighter, that bind more specifically, that have better biological activity or that have better safety profile. n A further embodiment of the invention comprises identifying or designing biologically-active moieties by the instant process. n In a further embodiment, a biomolecule crystal having an easily accessible active site is formed by co-crystallizing the biomolecule with a degradable ligand and degrading the ligand. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9290757-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8663633-B2 |
| priorityDate | 1998-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 328.