abstract |
There is disclosed an advantageous mixed acid anhydride production method of formula (1): n R 1 C(O)OY(O) n (R 2 ) p (1) n wherein R 1 , R 2 and Y denote the same as defined below, n and p denote an integer of 1 or 2, which is characterized by adding a carboxylic acid of formula (2); n R 1 COOH (2) n wherein R 1 denotes a hydrogen atom, an optionally substituted alkyl group or the like, an organic base to a solution of a carboxylic acid activating agent of formula (3); n (R 2 ) p Y(O) n X (3) n wherein R 2 denotes an optionally substituted aliphatic hydrocarbyl group or the like, Y denotes a carbon atom, a phosphorus atom, or a sulfur atom, and X denotes a chlorine atom or the like. |