| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a1cd7029ec038fa78d4b371f9bf08e9e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate |
2003-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02072a68ca926e3ef10615ce47c4012d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ce5a27b9362a7ff7b49d30c8ce3918b |
| publicationDate |
2004-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004209830-A1 |
| titleOfInvention |
System for monitoring the expression of transgenes |
| abstract |
A novel strategy for monitoring the expression of a transgene in a patient is disclosed. A marker peptide is genetically fused to either the N-terminus or C-terminus of the product of a transgene through a linker peptide which bears the recognition sequence of a host cell protease. Expression of the transgene results in release of the marker peptide into extracellular body fluid of the patient in proportion to the amount of transgene product. The level of the released marker peptide serves as an indicator of the level of transgene expression. The system is particularly useful for monitoring the expression of therapeutic transgenes and production of the therapeutic gene product. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010317096-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7714119-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7662623-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005003482-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004265955-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007059820-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005136035-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11634469-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7632509-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008280356-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9951117-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9428736-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006034805-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7498024-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7485291-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7709224-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009270485-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10752666-B2 |
| priorityDate |
1999-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |