abstract |
Triptolide analogues are described, including compounds of Formula I: n n n or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R 3 -R 6 , X and Y are set forth in the specification. The compounds of the invention are potent 15-lipoxygenase inducers. Pharmaceutical compositions of the compounds are also described. Also provided are methods for the treatment or prophylaxis of inflammatory and autoimmune disorders in a mammal by administering compounds of the invention. |