| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-82 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-82 |
| filingDate |
2003-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94eb8b0cd732460763eb5607e8c6f814
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c0a162361e6f0fe16dc684d9c76ce15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbf950235991011d5c7d8ce2025c23cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4195d70d1cdb10fe01f954f19f396a6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb76e7ad5a354d4a7ba5d15960910963 |
| publicationDate |
2004-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004197893-A1 |
| titleOfInvention |
HDM2-inhibitor complexes and uses thereof |
| abstract |
The present invention includes crystallized HDM2 peptides as well as descriptions of the X-ray diffraction patterns of the crystals. The diffraction patterns allow the three dimensional structure of HDM2 to be determined at atomic resolution so that ligand binding sites on HDM2 can be identified and the interactions of ligands with HDM2 amino acid residues can be modeled. Models prepared using such maps permit the design of ligands which can function as active agents which include, but are not limited to, those that function as inhibitors of MDM2 and HDM2 oncoproteins. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009312310-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8859776-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8034907-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013062923-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010267150-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009151069-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7705127-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005114173-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7632920-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111238458-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7888474-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8987274-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005037383-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846657-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008072655-A1 |
| priorityDate |
2002-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |