| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5bc5292a07e34d16eb1d033a16d3aec3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate |
2004-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_240f0e76258f59b417a62624fe0d6b75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8738e0d96f1483967b0947aecd001c54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86339f25253fc64bd3f7c3c94a8cefec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9af873a4f632dde393eac6d9b525a52a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d50c1281a3d6fd639f3d6272fcc07488 |
| publicationDate |
2004-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004197818-A1 |
| titleOfInvention |
MinK-related genes, formation of potassium channels and association with cardiac arrhythmia |
| abstract |
The present invention is directed to genes and gene products related to Min-K which form ion channels and to a process for diagnosis of ion channel disorders, including long QT syndrome (LQT). For example, KCNE2 forms I Kr potassium channels and is associated with LQT. LQT is diagnosed in accordance with the present invention by analyzing the DNA sequence of KCNE2 of an individual to be tested and comparing the respective DNA sequence to the known DNA sequence of a normal KCNE2 gene. Alternatively, these MinK-related genes of an individual to be tested can be screened for mutations which cause ion channel disorders, including LQT. Prediction of ion channel disorders, including LQT, will enable practitioners to prevent the disorders using existing medical therapy. This invention is further directed to the discovery that the HERG and KCNE2 (also known as MiRP1) proteins coassemble to form a cardiac I Kr potassium channel. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010189701-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013217779-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008079412-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008079412-A2 |
| priorityDate |
1999-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |