| abstract |
The invention provides novel adamantane compounds having one of the following formulas: n n n wherein: n R 1 and R 3 are H, OH, alkyl, cycloalkyl, amino or aryl, and can be the same or different; n R 2 is H, NH 2 , alkyl, OH, COOH, amino, amide, or carbamate; n R 4 -R 8 are H, OH, NH 2 , alkyl, OH, COOH, ester, amino, amide, or alkyloxy, and can be the same or different; n R 9 -R 14 are H, alkyl, or phenyl, and can be the same or different; n and wherein when any of R 1 -R 8 is amino, the compounds are the free bases and their acid addition salts. n The present invention also relates to compositions and methods for treating and/or preventing neurological and inflammatory disorders in a patient by administering a therapeutically effective amount of the compounds of formula (I), (II) or (III) and a pharmaceutically acceptable carrier. |